Treatment-Resistant Depression

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When Depression Has Not Improved Enough

Some people continue experiencing significant depression despite trying multiple treatments.

Treatment-resistant depression can be frustrating and exhausting, particularly when symptoms continue to affect relationships, work, sleep, motivation, and everyday functioning.

ThyrveBright provides specialized psychiatric consultations for individuals whose depression has not improved adequately with previous treatment approaches.

Understanding Treatment Resistance

A limited response to treatment can happen for many reasons.

Your provider may review:

  • Previous diagnoses
  • Medication history
  • Treatment duration
  • Medication response
  • Side effects
  • Current symptoms
  • Treatment adherence
  • Co-occurring psychiatric conditions
  • Medical factors
  • Previous treatment approaches


Looking Beyond The Current Medication

A detailed treatment review can help identify whether other factors may be contributing to persistent symptoms.

This may include untreated anxiety, trauma, sleep problems, medication effects, or other mental health concerns.

Exploring Additional Treatment Options

Depending on your clinical situation, your provider may discuss additional treatment approaches.

These may include medication changes, alternative psychiatric treatment strategies, specialized consultations, or consideration of Spravato® treatment when appropriate.

Spravato® Consultation

For certain eligible adults with treatment-resistant depression, Spravato® (esketamine) may be considered as part of a comprehensive treatment plan.

Eligibility requires careful evaluation and consideration of medical and psychiatric factors.

Individualized Care

Treatment-resistant depression does not look the same for every patient.

Our approach focuses on understanding what you have already tried, how you responded, and what options may reasonably fit your current needs.